BPIFB1 is a prognostic biomarker and mediated collagen synthesis in idiopathic pulmonary fibrosis.

ABSTRACT: It has been demonstrated that bactericidal/permeability-increasing-fold-containing family B member 1 (BPIFB1) is highly expressed in idiopathic pulmonary fibrosis (IPF) and is linked to a dismal prognosis; nevertheless, its molecular role and connection to lung function in IPF are still unknown. The Gene Expression Omnibus database provided the data. Functional enrichment analyses, Kaplan-Meier, Cox regression, and the Pearson correlation coefficient were applied. Studies and single-cell ribonucleic acid sequencing research verified the impact of BPIFB1 on IPF. BPIFB1 was highly expressed in differentiating ciliated cells and MUC5B + cells, and single-cell sequencing and transcriptome analysis revealed that it was up-regulated in the lungs of IPF; however, blood BPIFB1 expression was simil

SUBMITTER: Yang J 

PROVIDER: S-EPMC12129523 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature