Causal association between uterine fibroids and cardiovascular disease: A Mendelian randomization study.

ABSTRACT: Uterine fibroids (UF), the most common benign tumors in women, have been associated with cardiovascular disease (CVD) in observational studies, yet causal inference remains unclear due to confounding. This Mendelian randomization (MR) study leveraged genetic variants as instrumental variables (IVs) to evaluate the causal relationship between genetically predicted UF and CVD risk. Exposure data were derived from a UK Biobank genome-wide association study of 462,933 Europeans (5168 UF cases). Outcome data for CVD subtypes were obtained from FinnGen and EBI consortia (sample sizes: 180, 862-977, 323). Fourteen independent single-nucleotide polymorphisms strongly associated with UF (P < 5 × 10⁻⁶) were selected as IVs, pruned for linkage disequilibrium (r2<0.001; F-statistic > 10). The inverse-

SUBMITTER: Yao M 

PROVIDER: S-EPMC12129545 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature