Increased CCL18 expression infers a poor prognosis in glioblastoma multiforme and promotes U-87 MG cell proliferation and migration: A retrospective cohort study.

ABSTRACT: This study aims to investigate the role of C-C Motif Chemokine Ligand 18 (CCL18) in glioblastoma multiforme tissues. Glioblastoma multiforme-related gene expression, clinical parameters, and the corresponding expression data in normal tissues were obtained from The Cancer Genome Atlas database and The Genotype-Tissue Expression database, respectively. The expression levels of CCL18 in 1157 normal tissues, 166 glioblastoma multiforme tissues and its relationship with clinicopathological features were analyzed. The degree of immune infiltration in glioblastoma multiforme tissues was assessed using single sample gene set enrichment analysis algorithm and ESTIMATE algorithm. Gene set enrichment analysis was used to explore the biological processes and pathways that may be regulated by CCL18. U

SUBMITTER: Huang G 

PROVIDER: S-EPMC12129557 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature