Differentiation Defect Into GABAergic Neurons in Cerebral Organoids From Autism Patients.

ABSTRACT:

Objectives

Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects social communication and behaviors. While previous studies using animal models have substantially expanded our knowledge about ASD, the lack of an appropriate human model system that accurately recapitulates the human-specific pathophysiology of ASD hinders the precise understanding of its etiology and the development of effective therapies. This study aims to replicate pathological phenotypes in cerebral organoids derived from idiopathic ASD patients and to conduct proof-of-concept research for the development of ASD therapeutics.

Methods

We conducted an in vitro disease modeling study using cerebral organoids derived from three idiopathic ASD patients. Additionally, we performed organo

SUBMITTER: Hali S 

PROVIDER: S-EPMC12129711 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature