Anterior-temporal network hyperconnectivity is key to Alzheimer's disease: from ageing to dementia.

ABSTRACT: Curing Alzheimer's disease remains hampered by an incomplete understanding of its pathophysiology and progression. Exploring dysfunction in medial temporal lobe networks, particularly the anterior-temporal (AT) and posterior-medial (PM) systems, might provide key insights, because these networks exhibit alterations in functional connectivity along the entire Alzheimer's continuum, potentially influencing disease propagation. However, the specific changes in each network and their clinical relevance across stages are not yet fully understood. This requires consideration of commonly used biomarkers, clinical progression, individual variability and age confounds. Here, we leveraged monocentric longitudinal data from 261 participants spanning the adult lifespan and the Alzheimer's continuum. T

SUBMITTER: Chauveau L 

PROVIDER: S-EPMC12129740 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature