Decoupling of motor cortex to movement in Parkinson's dyskinesia rescued by sub-anaesthetic ketamine.

ABSTRACT: Gamma-band and single-unit neural activity in primary motor cortex are involved in the control of movement. This activity is disrupted in Parkinson's disease (PD) and levodopa-induced dyskinesia (LID), a debilitating consequence of dopamine replacement therapy for PD. Physiological features of LID include pathological narrowband gamma oscillations, finely tuned gamma and altered primary motor cortex firing activity. Given that most studies characterize LID through visual scoring, little is known about the relationships between ongoing dyskinetic movements, gamma and neuronal activity at fast (sub-second) and slow (seconds) time scales. Here, we investigate how motor cortex activity changes with movement at multiple time scales in animal models of PD and LID. Furthermore, sub-anaesthetic ke

SUBMITTER: Vishwanath A 

PROVIDER: S-EPMC12129741 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature