Ferroptosis-related gene signature-based subtype identification of triple-negative breast cancer to prioritize treatment strategies.

ABSTRACT:

Purpose

Ferroptosis, an iron-dependent form of regulated cell death (RCD), has been proven to affect the response to antineoplastic therapies. However, little is known about the role of ferroptosis in chemotherapy and immune checkpoint inhibitor (ICI) therapy responses, as well as the molecular subtype identification of triple-negative breast cancer (TNBC).

Methods

We performed unsupervised clustering to stratify patients with TNBC in the Fudan University Shanghai Cancer Center (FUSCC) TNBC cohort into distinct ferroptosis-related subtypes according to the expression of eight ferroptosis-related genes (FRGs): EMC2, FTH1, HMOX1, LPCAT3, NOX4, SOCS1, BAP1, and ISCU. We conducted Gene Ontology (GO) analysis and gene set variation analysis (GSVA) to characterize the immune pheno

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12129930 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature