Adjunctive intra-arterial thrombolysis after thrombectomy: Findings from the RITE registry.

ABSTRACT: BackgroundDespite the excellent recanalization rates following thrombectomy, significantly fewer patients have favorable outcomes. Impaired reperfusion of the microcirculation caused by distal thrombi could contribute to that, and adjunctive intraarterial thrombolysis such as alteplase (IA-tPA) might improve outcomes. We assessed the impact of adjunctive IA-tPA following thrombectomy with TICI score ≥ 2A on functional outcomes and reperfusion status.MethodsA retrospective analysis of patients with LVO ischemic stroke who underwent EVT. Patients were dichotomized into those who received EVT + IA-tPA vs EVT alone. Primary outcomes were favorable functional outcome (90-day mRS 0-2), and 90-day home-time.Results354 patients were included, of which 133 (37.6%) were treated with EVT + IA-tPA and

SUBMITTER: Eshetawe S 

PROVIDER: S-EPMC12129940 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature