B Cells as a Host of Persistent Salmonella Typhimurium.

ABSTRACT: Salmonella enterica serovar Typhimurium (S. Tm) can colonise different intracellular niches, either actively dividing or remaining dormant to persist. Bacterial persisters are phenotypic variants that temporarily enter a nonreplicative state. This allows them to evade host cell defences and antibiotics, leading to chronic infections. We previously reported that during chronic periods, Salmonella remains within B cells in the bone marrow and spleen. However, the dynamics of Salmonella replication and the formation of antibiotic tolerance in infected B cells have not been studied. Here we show that B cells are a favourable reservoir for bacterial persistence. In vitro and in vivo experiments identified non-replicating, persistent Salmonella subsets in splenic B cells. These non-replicative S

SUBMITTER: Cruz-Cruz AD 

PROVIDER: S-EPMC12130668 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature