Arteries are finely tuned thermosensors regulating myogenic tone and blood flow.

ABSTRACT: In response to changing blood pressure, arteries adjust their caliber to control blood flow. This vital autoregulatory property, termed vascular myogenic tone, stabilizes downstream capillary pressure. Here, we reveal that tissue temperature, combined with intraluminal pressure, critically determines myogenic tone. Heating steeply activates tone in skeletal muscle, gut, brain, and skin arteries with temperature coefficients (Q₁₀) of ~11 to 20. Each of these tissues has a distinct resting temperature, and we find that arterial thermosensitivity is tuned to this temperature, making myogenic tone sensitive to small thermal fluctuations. Interestingly, temperature and intraluminal pressure are sensed largely independently and the signals integrated to trigger myogenic tone. W

SUBMITTER: Phan TX 

PROVIDER: S-EPMC12130814 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature