Calcineurin controls the cytokinesis machinery during thermal stress in <i>Cryptococcus deneoformans</i>.

ABSTRACT: Calcineurin is a highly conserved phosphatase that plays a central role in sensing calcium and governing transcriptional, posttranscriptional, and posttranslational signaling networks. Calcineurin is a heterodimer consisting of a catalytic A subunit and a regulatory B subunit. Through downstream effectors, calcineurin signaling drives myriad responses in different organisms. In the fungal pathogenic Cryptococcus species complex that infects humans, calcineurin governs thermotolerance and is essential for growth at high temperature and pathogenesis. In Cryptococcus deneoformans, the underlying molecular functions of this critical signaling cascade are not well understood. In this study, we conducted a genetic screen and identified genetic changes that suppress the requirement

SUBMITTER: Yadav V 

PROVIDER: S-EPMC12130876 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature