In vivo quantitative proteomic analysis of porcine alveolar macrophages in PRRSV-infected pigs.

ABSTRACT: Porcine reproductive and respiratory syndrome (PRRS), a highly infectious immunosuppressive disease caused by porcine reproductive and respiratory syndrome virus (PRRSV), has led to significant economic losses in the global swine industry. The complexity of preventing and controlling PRRS, compounded by the limited efficacy of current vaccines, underscores the urgent need to identify antiviral targets and develop effective therapeutics against PRRSV. From the perspective of virus-host interactions, the discovery of target molecules associated with PRRSV resistance offers a promising strategy for future disease management. In this study, we conduct a comprehensive proteomic analysis using data-independent acquisition (DIA) mode to investigate the host response throughout the acute phase of

SUBMITTER: Wei Y 

PROVIDER: S-EPMC12131027 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature