Weight-adjusted waist index and deficit accumulation frailty trajectories in middle-aged and older adults: a longitudinal study.

ABSTRACT:

Introduction

Previous studies indicated that obesity defined by BMI accelerate frailty, but this effect weakens when stratified by metabolic status. The Weight-adjusted Waist Index (WWI), a better indicator of central obesity, may provide a more accurate measurement. The primary aim of this study was to estimate the impact of WWI on frailty progression and compare its effects across different metabolic statuses.

Methods

We used data from 10,440 participants aged 45 and older from the China Health and Retirement Longitudinal Study (CHARLS).The Frailty Index (FI) was derived from 32 health deficits. K-means clustering identified three trajectories for WWI or BMI: stable low, stable moderate, and stable high. Longitudinal associations were assessed using Accelerated Failure Tim

SUBMITTER: Zeng P 

PROVIDER: S-EPMC12131399 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature