Around-the-clock noise exposure induces hippocampus apoptosis and subsequent cognitive impairment via the PI3K/SGK1/Foxo3 signaling pathway.

ABSTRACT:

Background

Noise exposure is an environmental stressor associated with cognitive impairment. Workers in specific work environments are often exposed to around-the-clock noise and experience severe emotional and cognitive dysfunctions associated with neuropathology similar to Alzheimer's disease. However, the underlying neural mechanisms have not been extensively investigated.

Methods

The molecular pathways underlying cognitive impairment following around-the-clock noise exposure were evaluated using male Wistar rats. The open-field and Morris water maze tests were used to assess cognitive performance. RNA sequencing was employed to identify key regulators and pathological pathways of cognitive impairment. Histological changes were observed using hematoxylin and eosin stainin

SUBMITTER: Fu Y 

PROVIDER: S-EPMC12131575 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature