Using vascular biomarkers to assess heart failure event risk in hospitalized patients with and without AKI.

ABSTRACT:

Background

Patients with AKI experience higher rates of heart failure (HF). This study seeks to identify criteria to assess the risk of heart failure post-hospitalization, with a special focus on AKI patients. We hypothesized that the combined use of 9 vascular biomarkers would predict future heart failure events after AKI. Using a study of 1497 hospitalized patients with and without AKI, we found that these 9 vascular biomarkers successfully stratified patients into different risk groups for HF, and were able to improve prediction of HF when added to routine clinical variables.

Methods

Using the ASSESS-AKI cohort, we performed an unsupervised spectral cluster analysis with 9 plasma biomarkers measured at 3 months post-hospitalization [Angiopoietin (angpt)-1, angpt-2, vascul

SUBMITTER: Shi AA 

PROVIDER: S-EPMC12131712 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature