Genomics-based approach for detection and characterization of SARS-CoV-2 co-infections and diverse viral populations.

ABSTRACT: Due to the continuous genetic diversification of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) over time, the co-circulation of two different lineages in the same region may lead to co-infections within a host, a situation known to contribute to the emergence of hybrid viral populations through genomic recombination. The aim of this study was to use a genomics-based approach to identify distinct viral populations of SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19), as an indicator of potential co-infections and recombination events. The cohort included 41,224 serial nasopharyngeal swabs positive for SARS-CoV-2 RNA, prospectively collected between January 2021 and April 2022 as part of the French national surveillance program. Full-length genomes were sequ

SUBMITTER: Jimenez-Araya B 

PROVIDER: S-EPMC12131723 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature