Regulation of the promoter for capsular polysaccharide synthesis in <i>Neisseria meningitidis</i> serogroup B by HTH_XRE family transcription factor.

ABSTRACT: The capsular polysaccharide synthesis (cps) locus of Neisseria meningitidis is implicated in invasive meningococcal disease. The synthesis (synABCD) and transport (ctrABCD) operons are transcribed in opposite directions from a common intergenic region, and the expression is negatively regulated by the bacterial two-component system (TCS) misR/misS and thermosensitive RNA folding. However, these mechanisms do not fully explain the stationary phase responses, and the cis-acting elements remain to be fully characterized. Using the GFP reporter gene and site-directed mutagenesis, cis-regulatory elements in the 134 bp intergenic region, NmIR, were investigated. While confirming a known RpoD promoter, an additional potential promoter element and p

SUBMITTER: Sofowora I 

PROVIDER: S-EPMC12131743 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature