Identification of 1,400 metabolites as mediators of obesity in 473 gut microbiota taxa: a mediation Mendelian randomization study.

ABSTRACT: Obesity is a global health problem driven by genetic, endocrine, and environmental factors. Gut microbiota significantly influences obesity, yet causal relationships and underlying pathways remain elusive. The objective of the study was to investigate causal relationships between gut microbiota, metabolites, and obesity; elucidate potential pathways mediating obesity onset; identify novel genes; and explore the impact of plasma proteins on obesity risk. Bidirectional and two-sample Mendelian randomization (MR) were used to explore causal relationships. Mediation analyses identified mechanisms linking gut microbiota, metabolites, and obesity. Pathway analyses and protein-protein interaction assessed genetic and protein associations. The MR analysis results identified 11 gut microbiota speci

SUBMITTER: Li X 

PROVIDER: S-EPMC12131829 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature