Phylogenomic associations among methicillin-resistant <i>Staphylococcus aureus</i> isolates derived from pets, dairies, and humans.

ABSTRACT: Methicillin resistance in Staphylococcus aureus is conferred by the mobile genetic element, staphylococcal cassette chromosome mec (SCCmec). Methicillin-resistant Staphylococcus aureus (MRSA) can transmit among animals and humans, leading to persistence and back transmission events. The current study tested the hypothesis that companion animal and livestock-associated (LA) MRSA isolates share genomic similarity, suggesting shared ancestry with hospital-associated (HA) or community-associated (CA) MRSA. Eight S. aureus isolates from therapy dogs (n = 5) and bulk tank milk (n = 3) were genome sequenced, and 71,721 genome-wide single nucleotide polymorphism (SNP) locations were extracted and phylogenetically compared against methicillin-

SUBMITTER: Krueger M 

PROVIDER: S-EPMC12131838 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature