Prevalence and molecular characterization of human bocavirus in children with acute gastroenteritis in Beijing, China, during 2014-2023.

ABSTRACT: Human bocavirus (HBoVs) is an emerging virus globally, and its prevalence, diversity, and evolution in children with acute gastroenteritis require further study. Fecal specimens collected from outpatients with acute gastroenteritis in Beijing, China, from April 2014 to December 2023, were tested for HBoVs by PCR targeting the NS1 gene. Genotyping was based on the NP1/VP1 boundary region, and nearly full-length HBoV2 sequences were analyzed phylogenetically. A total of 79 HBoVs-positive specimens (2.5%, 79/3,116, 95% CI: 2.0%-3.1%) were detected, with HBoV2 (65.8%, 52/79, 95% CI: 55.4%-76.3%) as the dominant genotype, followed by HBoV1 (25.3%, 20/79, 95% CI: 15.7%-34.9%) and HBoV3 (8.9%, 7/79, 95% CI: 2.6%-15.1%). HBoVs were distributed throughout the year, with higher positive rates observ

SUBMITTER: Li Z 

PROVIDER: S-EPMC12131841 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature