Cordycepin ameliorates diabetic nephropathy injury by activating the SLC7A11/GPX4 pathway.

ABSTRACT:

Background

Cordycepin (CRD) has been identified to alleviate diabetes-induced injuries and complications including diabetic nephropathy (DN). Here, this work focused on probing the specific effects and potential mechanisms of CRD on DN progression.

Methods

High glucose (HG)-induced mouse podocyte cell line (MPC5) was used for in vitro functional analyses. Cell proliferation and apoptosis were determined using cell counting kit-8 assay, 5-ethynyl-2'-deoxyuridine assay, and flow cytometry, respectively. ELISA analysis detected inflammatory factors. Cell ferroptosis was assessed by measuring the levels of Fe2+, glutathione, reactive oxygen species, and malonaldehyde.

Results

CRD treatment suppressed HG-induced apoptosis, inflammation, and ferroptosis in podocytes. CRD tr

SUBMITTER: Wu B 

PROVIDER: S-EPMC12131933 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature