Slowing the spread of treatment failure to artemisinin-based combination therapies in Uganda.

ABSTRACT:

Background

The multiple emergences and continuing spread of partially artemisinin-resistant Plasmodium falciparum in Africa, where about 95% of malaria occurs, is a health challenge that requires urgent attention. The World Health Organization has developed a resistance response strategy that centers on enhancing surveillance, reducing drug pressure, and evaluating novel tools to slow resistance evolution which includes the deployment of multiple first-line therapies (MFT). Developing a specific resistance response is critical for Uganda, where four pfkelch13 mutations are at local allele frequencies >0.20.

Methods

Using a previously validated Uganda-calibrated individual-based mathematical model of P. falciparum transmission and evolution, we evaluated

SUBMITTER: Nguyen TD 

PROVIDER: S-EPMC12132124 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature