Cortical connectivity predicts cognition across time in Parkinson's disease.

ABSTRACT: Cognitive symptoms are common in Parkinson's disease (PD), yet the underlying brain mechanisms remain poorly understood. To address this gap, we investigated the relationship between functional connectivity and cognition at multiple time points using longitudinal functional MRI (fMRI) and cognitive assessments from the Parkinson's Progression Marker Initiative (PPMI). We calculated resting-state functional connectivity within and between three key cortical brain networks that have been linked with cognitive function in PD: the frontoparietal network (FPN); the salience network (SAL); and the default mode network (DMN). Cognitive function was assessed with the Montreal Cognitive Assessment (MoCA). Linear mixed-effects modeling revealed that decreased FPN-DMN functional connectivity is assoc

SUBMITTER: Twedt HP 

PROVIDER: S-EPMC12132129 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature