Characterizing Parkinson's Disease Clinical and Biomarker Interactions in REM Sleep Behavior Disorder.

ABSTRACT:

Background

REM Sleep Behavior Disorder (RBD), marked by dream enactment due to loss of REM-related muscle atonia, is a prominent prodromal indicator of synucleinopathies, particularly Parkinson's Disease (PD).

Objectives

This study aimed to investigate the interplay among key PD biomarkers- α-synuclein seed amplification assay (SAA), hyposmia, and dopamine transporter (DaT) SPECT imaging - in individuals with RBD. Additionally, we evaluated how phenoconversion events and Movement Disorder Society (MDS)-Prodromal PD probability scores relate to clinical symptoms and biomarker profiles in an incident RBD population.

Methods

Participants with polysomnographically-confirmed RBD underwent comprehensive clinical and biomarker assessments. They were grouped along three non-e

SUBMITTER: Reddy VL 

PROVIDER: S-EPMC12132163 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature