Human Applications of Transcranial Temporal Interference Stimulation: A Systematic Review.

ABSTRACT:

Background

Many neurological and psychiatric disorders involve dysregulation of subcortical structures. Transcranial temporal interference stimulation (tTIS) is a novel, non-invasive method developed to selectively modulate these regions and associated neural circuits.

Methods

A systematic review was conducted to evaluate human applications of tTIS (PROSPERO ID: CRD42024559678). MEDLINE, Embase, APA PsycINFO, CENTRAL, ClinicalTrials.gov, and WHO ICTRP were searched up to December 12, 2024. Studies involving human applications of tTIS were eligible. Methodological quality was appraised using the NIH and modified Oxford Centre for Evidence-Based Medicine tools.

Results

Forty-eight records were reviewed (20 published studies, 28 ongoing trials). Of published studies, 16

SUBMITTER: Demchenko I 

PROVIDER: S-EPMC12132165 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature