Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization.

ABSTRACT: Two component systems (TCS) mediate bacterial signal transduction in response to specific environmental conditions. The two components are the sensor kinase (SK), which senses the signal and autophosphorylates on a histidine residue, and a response regulator (RR), which is phosphorylated by the kinase and modifies gene expression. Despite intensive study, the mechanisms of signal sensing by sensor kinases are incompletely defined and the mechanisms by which SKs can sense multiple ligands are unclear. Mycobacterium tuberculosis PdtaS/PdtaR is a soluble TCS pair that participates in the Rip1 signal transduction cascade to control virulence by responding to copper and nitric oxide (NO). In contrast to paradigmatic ligand activated SKs, PdtaS is constitutively active without ligand and

SUBMITTER: Sankhe GD 

PROVIDER: S-EPMC12132213 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature