A Y-linked duplication of anti-Mullerian hormone is the sex determination gene in threespine stickleback.

ABSTRACT: Many taxa have independently evolved genetic sex determination where a single gene located on a sex chromosome controls gonadal differentiation. The gene anti-Mullerian hormone (amh) has convergently evolved as a sex determination gene in numerous vertebrate species, but how this gene has repeatedly evolved this novel function is not well understood. In the threespine stickleback (Gasterosteus aculeatus), amh was duplicated onto the Y chromosome (amhy) ~22 million years ago. To determine whether amhy is the primary sex determination gene, we used CRISPR/Cas9 and transgenesis to show that amhy is necessary and sufficient for male sex determination, consistent with the function of a primary sex determination gene. Despite being indispensable for sex

SUBMITTER: Treaster MJ 

PROVIDER: S-EPMC12132230 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature