Alcohol Use Disorder Associated Gene <i>FNDC4</i> Alters Glutamatergic and GABAergic Neurogenesis.

ABSTRACT: Large-cohort genome-wide association studies (GWAS) for alcohol use disorder (AUD) and AUD-related phenotypes have identified more than one hundred genetic loci. Functional study of those GWAS-identified loci might represent an important step toward understanding AUD pathophysiology. We found that genetic loci which are splicing quantitative trait loci (sQTLs) for the fibronectin III domain containing 4 (FNDC4) gene in the brain were identified by GWAS for both AUD drug treatment outcomes and AUD risk. However, FNDC4 function in the brain and how it might contribute to AUD pathophysiology remain unknown. In the present study, we characterized GWAS locus-associated FNDC4 splice isoforms, studies which suggested that FNDC4 alternative splicing results in loss-of-function

SUBMITTER: Zhu X 

PROVIDER: S-EPMC12132278 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature