Entry Steps in the Biosynthetic Pathway to Diterpenoid Alkaloids in <i>Delphinium grandiflorum</i> and <i>Aconitum plicatum</i>.

ABSTRACT: Roots from the Aconitum (Wolf's-Bane) and Delphinium (Larkspur) genera have been widely used in traditional medicine owing to the abundance of bioactive diterpenoid alkaloids that they produce. Despite extensive research on these compounds and their potential medicinal applications, their structural complexity precludes their production through total chemical synthesis, and little progress has been made towards elucidation of their biosynthetic pathways. Here, we report the entry steps in the biosynthesis of the diterpenoid alkaloid atisinium, constituting six enzymes identified from the Siberian Larkspur (Delphinium grandiflorum) and garden monkshood (Aconitum plicatum) through a combination of comparative transcriptomics between tissue types and genera and coe

SUBMITTER: Miller GP 

PROVIDER: S-EPMC12132485 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature