Randomized field trial of a therapeutic vaccine against <i>Trypanosoma cruzi</i> natural infection in dogs and correlates for efficacy.

ABSTRACT:

Background and aims

Chagas disease, caused by Trypanosoma cruzi, is a vector-borne parasitic disease, with dogs acting as a major domestic host of the parasite. An immunotherapeutic vaccine would be an excellent tool to treat infections and prevent chronic cardiac disease in this host. Building on previous pre-clinical studies, we performed here the first randomized field trial of a vaccine against T. cruzi among client-owned dogs with natural infections.

Methods

A total of 31 dogs with T. cruzi infection with diverse parasite strains were enrolled and received three doses of a vaccine composed of Tc24-C4 and TSA1-C4 recombinant proteins with MPLA (N=16) or saline control (N=15) and followed for up to six months to assess efficacy.

Results

Blood p

SUBMITTER: Calderon-Quintal JA 

PROVIDER: S-EPMC12132542 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature