The fungal peptide toxin candidalysin induces distinct membrane repair mechanisms compared to bacterial pore-forming toxins.

ABSTRACT: The common fungal pathogen, Candida albicans, relies on the pore-forming toxin candidalysin to damage host cells. Cells resist other pore-forming toxins by Ca²⁺ dependent microvesicle shedding and annexins (cholesterol-dependent cytolysins, CDCs), or annexins and patch repair (aerolysin). However, it is unclear which Ca²⁺ dependent repair mechanism(s) resists candidalysin. Here, we determined the involvement of different Ca²⁺ dependent repair mechanisms to candidalysin and compared responses to CDCs and aerolysin using flow cytometry and high-resolution microscopy. We report that candidalysin triggered Ca²⁺-dependent repair, but patch repair and ceramide failed to provide significant protection. MEK-dependent repair and annexins A1, A2 and

SUBMITTER: Thapa R 

PROVIDER: S-EPMC12132583 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature