Exploration of Conserved Human Adipose Subpopulations Using Targeted Single-Nuclei RNA Sequencing Data Sets.

ABSTRACT:

Background

Smooth-muscle cells and pericytes are mural cells. Pericytes can differentiate into myofibroblasts, chondrocytes, vascular smooth-muscle cells, and adipocytes, marking them as a distinct progenitor population. Our goal was to molecularly define the progenitor cell populations in human adipose tissues and test the adipogenic potential of human mural cells.

Methods

We used informatic analysis of single-cell RNA sequencing data from human tissues to identify and define pericytes and adipose progenitor cells found in human adipose tissues, including perivascular, brown, and white adipose tissues.

Results

We established tissue-specific patterns of gene expression in pericytes and other putative human adipocyte progenitor cells. PPARG-expressing pericytes

SUBMITTER: Potts CM 

PROVIDER: S-EPMC12132619 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature