<i>RNF213</i> Variant and Infectious Burden Associated With Intracranial Artery Stenosis in Moyamoya Disease.

ABSTRACT:

Background

The mechanisms driving the progression of moyamoya disease (MMD) remain unrecognized. There is evidence suggesting that genetic and environmental factors may be associated with intracranial artery stenosis. Here, we aimed to investigate the characteristics of infectious exposure and the association of the RNF213 (RING finger protein 213) variant and infectious burden (IB) with intracranial artery stenosis of MMD.

Methods and results

We prospectively recruited 275 patients with MMD. Participants underwent RNF213p.R4810K sequencing. Serum antibody titers of herpes simplex virus, cytomegalovirus, toxoplasma, rubella virus, and Epstein-Barr virus were assessed and combined into an IB score. The degree of intracranial artery stenosis was measured by using

SUBMITTER: Zeng C 

PROVIDER: S-EPMC12132687 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature