Extracellular Matrix Proteins Improve Risk Prediction in Patients Undergoing Transcatheter Aortic Valve Replacement.

ABSTRACT:

Background

Cardiac fibrosis is common in patients with severe aortic stenosis and an independent predictor of death. Therefore, we examined the additional value of circulating fibrosis markers as a putative biomarker platform to identify patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR) who are at a higher risk of death.

Methods

In this study, 2-year survival analyses were conducted in 378 consecutive patients undergoing TAVR to evaluate the association between fibrosis marker and risk of adverse long-term outcome. Implementation of fibrosis marker into TAVR risk stratification was tested by a machine-learning algorithm.

Results

Among 20 circulating fibrosis markers involved in pathological extracellular matrix remodeling, high tis

SUBMITTER: Boeckling F 

PROVIDER: S-EPMC12132695 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature