Myocardial Proteome in Human Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all HF but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have identified major differences between HFpEF and controls. How this translates at the protein level is unknown.

Methods and results

Myocardial tissue from patients with HFpEF and nonfailing donor controls was analyzed by data-dependent acquisition (n=10 HFpEF, n=10 controls) and data-independent acquisition (n=44 HFpEF, n=5 controls) mass spectrometry-based proteomics. Differential protein expression analysis, pathway overrepresentation, weighted coexpression network analysis, and machine learning were integrated with clinical characteristics and previously reported transcriptomics.

SUBMITTER: Jani VP 

PROVIDER: S-EPMC12132713 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature