Effect of Intensive Blood Pressure Control and Comorbidity Status on the Prognosis of Patients With Hypertension: Insights From SPRINT.

ABSTRACT:

Background

Hypertension is common and leads to negative outcomes. Intensive blood pressure (BP) lowering can reduce cardiovascular events and all-cause mortality, but its benefits for patients with hypertension with multiple comorbidities are uncertain. This study aimed to explore how comorbidities affect the clinical outcomes of intensive BP lowering in participants from the SPRINT (Systolic Blood Pressure Intervention Trial).

Methods

We analyzed data from the SPRINT data set and calculated each patient's comorbidity score using the Charlson Comorbidity Index (CCI). The primary end point was major adverse cardiovascular and cerebrovascular events, including cardiovascular death, heart failure, myocardial infarction, acute coronary syndrome not leading to myocardial infarcti

SUBMITTER: Zheng W 

PROVIDER: S-EPMC12132750 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature