Multi-Trait Polygenic Risk Score, Nongenetic Determinants, and Cardiovascular Disease Death: A Cohort Study of 14 086 Japanese Individuals.

ABSTRACT:

Background

Although utility of composite trait-specific polygenic risk score (multi-trait PRS) has been examined among European ancestries, few studies investigated among East Asians and incorporated modifiable risk factors. We examined the associations of multi-trait PRS for cardiometabolic factors with cardiovascular disease mortality by integrating nongenetic determinants.

Methods

A total of 14 086 Japanese participants (mean age, 55±9; 55.8% women) of the J-MICC (Japan Multi-Institutional Collaborative Cohort) study were analyzed in this study. We calculated 6 PRSs for cardiometabolic traits (systolic blood pressure, body mass index, triglycerides, low-density lipoprotein cholesterol, estimated glomerular filtration rate, and hemoglobin A1c). Based on these PRSs, we deve

SUBMITTER: Fujii R 

PROVIDER: S-EPMC12132758 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature