Association of Kidney Function With Incident Heart Failure: An Analysis of the Women's Health Initiative.

ABSTRACT:

Background

Studies have shown an association of chronic kidney disease with heart failure (HF); however, this association has not been adequately examined in postmenopausal women, who are at heightened risk of both chronic kidney disease and HF. Additionally, association with HF subtypes is not well characterized.

Methods and results

Incident HF was defined as first hospitalization for acute decompensated HF, obtained by self-reported outcomes followed by physician adjudication through review of hospital records. Chronic kidney disease was defined using estimated glomerular filtration rate (eGFR). Restricted cubic splines tested the association of eGFR with incident overall HF, and HF with reduced ejection fraction (HFrEF) and preserved EF (HFpEF). Cox proportional hazards r

SUBMITTER: Cheng RK 

PROVIDER: S-EPMC12132762 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature