Polygenic Risk and Cardiovascular Event Risk in Patients With Atrial Fibrillation With Low to Intermediate Stroke Risk.

ABSTRACT:

Background

The clinical utility of the polygenic risk score in predicting cardiovascular events in patients with atrial fibrillation (AF) has not yet been established. This study aimed to determine whether the polygenic risk score for AF might be useful in the risk stratification of AF-related cardiovascular events.

Methods and results

This study included 9597 oral anticoagulation-naive patients with AF with a CHA₂DS₂-VA (congestive heart failure; hypertension; age ≥75 years; diabetes; prior stroke or transient ischemic attack or thromboembolism; vascular disease; and age 65-74 years) score of 0 or 1 from the UK Biobank. Patients were stratified according to polygenic risk score tertiles and observed for the occurrence of ischemic stroke or systemic emb

SUBMITTER: Kim J 

PROVIDER: S-EPMC12132817 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature