Progression of Carotid Intima-Media Thickness in Children of the Cardiovascular Comorbidity in Children With Chronic Kidney Disease Study: Risk Factors and Impact of Blood Pressure Dynamics.

ABSTRACT:

Background

Carotid intima-media thickness (cIMT) may identify early alterations in the vascular phenotype in children with chronic kidney disease (CKD).

Methods and results

Investigation of longitudinal changes in cIMT SD scores (SDS) in 670 patients from the 4C Study (Cardiovascular Comorbidity in Children With CKD Study), aged 6 to 17 years, with CKD stage 3 to 5 at baseline. The longitudinal trajectory of cIMT SDS over up to 8 years was examined using a longitudinal mixed-effects model. The yearly progression rate in cIMT SDS (β=0.20 [95% CI, 0.13-0.28]) remained positive during the initial 4.5-year follow-up period but slowed down quadratically with increasing observation time (β=-0.02 [95% CI, -0.03 to -0.01]). Risk factors for increased cIMT SDS included time since bas

SUBMITTER: Doyon A 

PROVIDER: S-EPMC12132822 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature