Spontaneous Coronary Artery Dissection and a Family History of Aortic Dissection: A Genetic Association Study.

ABSTRACT:

Background

Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndrome or sudden cardiac death, primarily affecting relatively young women (median age, 51 years) without typical cardiovascular risk factors. SCAD has a genetic component, with genome-wide association studies identifying multiple risk loci. Thoracic aortic dissection (type A) shares some genetic overlap with SCAD, suggesting potential common predispositions.

Methods

We performed genetic screening or whole-genome sequencing of 17 patients with SCAD (94% women) with a first- or second-degree relative (89% men) affected by aortic dissection (AD). We assessed rare variants in candidate genes and genome-wide using the American College of Medical Genetics and Genomics

SUBMITTER: McGrath-Cadell L 

PROVIDER: S-EPMC12132886 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature