Prevalence and Associated Explanatory Factors for Augmented Renal Clearance in Early Sepsis: Single-Center, Retrospective PICU Cohort in China, 2022-2023.

ABSTRACT:

Objectives

We aimed to 1) evaluate the prevalence of augmented renal clearance (ARC) in pediatric sepsis patients; 2) analyze potential explanatory factors associated with ARC out of hemodynamic, oxygenation, and inflammatory parameters; and 3) assess ARC outcomes.

Design

Retrospective, single-center, cohort from January 2022 to June 2023.

Setting

PICU at a tertiary care hospital in China.

Patients

Children 28 days to 16 years of age admitted with sepsis defined using Phoenix Sepsis Criteria.

Interventions

None.

Measurements and main results

Among 69 patients, 34 (49.3%) were categorized as having ARC. Designation as having ARC, vs. not, was associated with being younger (median 2.4 vs. 7.2 years, p < 0.001), hemodynamic and intrarenal flow change

SUBMITTER: Xu L 

PROVIDER: S-EPMC12133050 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature