Cuproptosis-related gene signatures define the immune microenvironment in diabetic nephropathy.

ABSTRACT:

Background

Cuproptosis may be a new clue to illustrate the pathogenesis of the disease. There was no study focused on the relationship between the cuproptosis genes and diabetic nephropathy (DN). This study aimed to reveal the relationship between cuproptosis genes and the immune microenvironment in DN and distinguish different phenotypes to describe disease heterogeneity through consensus clustering based on cuproptosis genes.

Methods

We downloaded RNA sequencing data sets of DN glomerular and normal renal tissue samples (GSE142025, GSE30528, and GSE96804) from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) between DN and control samples were screened. Immune cell subtype infiltration and immune score were figured out via different algorit

SUBMITTER: Luo H 

PROVIDER: S-EPMC12133194 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature