Cross-sectional Associations of Neighborhood Social and Environmental Contextual Factors with Telomere Length in Male and Female Health Professionals.

ABSTRACT:

Background

Telomere length attrition has been proposed as a mediator through which the adverse neighborhood social and environmental context affects cancer risk through stress-related pathways, but associations have been inconsistent. We examined associations between neighborhood social and environmental factors in a population with extensive capture of behavioral factors and comorbidities.

Methods

Data were pooled from nested case-control studies using blood samples collected in two large prospective US-based cohorts of male (n = 3,065) and female (n = 9,993) health professionals. Relative leukocyte telomere length was assayed using qPCR and geospatial measures of socioeconomic status, air pollution, green space, and temperature were linked to participants' address at blood

SUBMITTER: Iyer HS 

PROVIDER: S-EPMC12133406 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature