Effect of microglial Pd1 on glial scar formation after spinal cord injury in mice.

ABSTRACT: The cross talk between microglia and astrocytes following spinal cord injury (SCI) greatly decides the prognosis. However, a comprehensive understanding of the molecular mechanisms by which microglia regulate astrocytic activity post-SCI is lacking. Programmed cell death protein 1 (Pdcd1, Pd1) plays a crucial role in modulating immune responses by exerting suppressive effects on microglia and peripheral immune cells within the central nervous system. Previous studies have shown the involvement of Pd1 in the pathogenesis of SCI; however, the role of microglial Pd1 in astrocytic activation and the following glial scar formation remains elusive. Here, we demonstrated that the pharmacological depletion of microglia using minocycline decreased the expression of tumor necrosis factor-alpha and i

SUBMITTER: Cai Y 

PROVIDER: S-EPMC12133710 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature