Selenium deficiency is functionally linked with the molecular etiopathogenesis of necrotizing enterocolitis (NEC).

ABSTRACT: Necrotizing enterocolitis (NEC) is a severe and often catastrophic gastrointestinal emergency that predominantly affects neonates, especially those born prematurely, and is associated with high rates of morbidity and mortality. Despite its significant clinical impact, the precise etiology and molecular pathogenesis of NEC remain incompletely understood. In this study, we conducted global transcriptomic profiling using high-throughput RNA sequencing in 11 premature neonates diagnosed with NEC, following rigorous inclusion and exclusion criteria. Compared to healthy controls, we identified 1,204 differentially expressed genes (DEGs), including 636 upregulated and 568 downregulated transcripts. Notably, genes involved in hypoxia-induced apoptosis (e.g., HIF1 AAS3, HIF1 AAS1), the caspase casc

SUBMITTER: Gurunluoglu K 

PROVIDER: S-EPMC12134042 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature