Osteocyte necroptosis drives osteoclastogenesis and alveolar bone resorption during orthodontic tooth movement.

ABSTRACT: Orthodontic tooth movement (OTM) has been described as a bone remodeling process mediated by the expression of various inflammatory cytokines, including tumor necrosis factor-α (TNF-α). Necroptosis is a form of regulated cell death that is mainly induced by TNF-α, leading to the release of damage-associated molecular patterns (DAMPs) that cause inflammation. However, the role of osteocyte necroptosis in regulating osteoclastogenesis during OTM remains unclear. Here, we investigated the effects of osteocyte necroptosis on osteoclastogenesis in a mouse model of OTM. In wild-type mice, osteocyte death was remarkably increased on day 6 after OTM. Transmission electron microscopy identified apoptotic osteocytes, necrotic osteocytes, and empty lacunae based on morphological characteristics. TNF

SUBMITTER: Ohori F 

PROVIDER: S-EPMC12134139 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature