IGF2BP2 regulates gastric cancer radiotherapy resistance through HIF1α-mediated glycolysis.

ABSTRACT: This study reveals the core mechanism by which insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) drives tumor progression and radiotherapy resistance in gastric cancer (GC) through m⁶A-dependent regulation of hypoxia-inducible factor 1α (HIF1α). Clinical analyses show that IGF2BP2 is significantly overexpressed in gastric cancer tissues, and its expression level is closely associated with tumor size and poor patient prognosis. Functional studies demonstrate that elevated expression of IGF2BP2 accelerates the transition of gastric cancer cells from the G1 phase to the G2/M phase of the cell cycle and markedly enhances cell proliferation and migration through anti-apoptotic effects. Mechanistically, IGF2BP2 specifically binds to the m⁶A-modified "GGACU" moti

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12134386 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature