Synthetic RNA ligands as activators of type I toxin-antitoxin systems: a novel antimicrobial strategy targeting <i>Helicobacter pylori</i>.

ABSTRACT: Targeting RNAs with synthetic small molecules represents a privileged avenue for the discovery of new therapeutic approaches and offers the possibility to identify original targets escaping the classical rules of druggability and resistance. In the context of multidrug resistance to antibiotics, an urgent need for new antimicrobial compounds is emerging; however both academia and industry are mostly working on known extensively explored targets susceptible to inducing resistance again. In this work, we present a new potential target for antibiotics represented by a Helicobacter pylori type I toxin-antitoxin system where RNA-RNA interactions are responsible for silencing the synthesis of a toxin that is lethal to bacteria and that is activated only under particular conditions. We rep

SUBMITTER: Martin C 

PROVIDER: S-EPMC12134931 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature