Neuroprotective Riluzole-Releasing Electrospun Implants for Spinal Cord Injury.

ABSTRACT: Spinal cord injury (SCI) results in paralysis, driven partly by widespread glutamate-induced secondary excitotoxic neuronal cell death in and around the injury site. While there is no curative treatment, the standard of care often requires interventive decompression surgery and repair of the damaged dura mater close to the injury locus using dural substitutes. Such intervention provides an opportunity for early and local delivery of therapeutics directly to the injured cord via a drug-loaded synthetic dural substitute for localized pharmacological therapy. Riluzole, a glutamate-release inhibitor, has shown neuroprotective potential in patients with traumatic SCI, and therefore, this study aimed to develop an electrospun riluzole-loaded synthetic dural substitute patch suitable for the trea

SUBMITTER: Ullrich MM 

PROVIDER: S-EPMC12135059 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature